2′-Fluoroacetophenone CAS 445-27-2 Purity >98.0% (GC)

Short Description:

Chemical Name: 2′-Fluoroacetophenone

Synonyms: 1-(2-Fluorophenyl)ethanone

CAS: 445-27-2

Purity: >98.0% (GC)

Appearance: Colorless to Light Yellow Liquid

High Quality, Commercial Production

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 2'-Fluoroacetophenone (CAS: 445-27-2) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	2'-Fluoroacetophenone
Synonyms	o-Fluoroacetophenone; 2-Fluoroacetophenone; 1-(2-Fluorophenyl)ethanone; 1-(2-Fluorophenyl)ethan-1-one
CAS Number	445-27-2
CAT Number	RF2963
Stock Status	In Stock, Production Capacity 20 Tons per Month
Molecular Formula	C8H7FO
Molecular Weight	138.14
Boiling Point	82.0~83.0℃/10 mmHg
Flash Point	61℃(141°F)
Solubility	Soluble in Acetone, Chloroform, Dichloromethane, Ethanol, Ethyl Acetate and Methanol
Hazard Class	Irritant
Packing Group	III
HS Code	29147090
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	Colorless to Light Yellow Liquid
Purity / Analysis Method	>98.0% (GC)
Density (20℃)	1.139~1.142
Refractive Index n20/D	1.507~1.509
1 H NMR Spectrum	Consistent With Structure
LCMS	Consistent With Structure
Water (by Karl Fischer)	<0.50%
Total Impurities	<2.00%
Test Standard	Enterprise Standard
Usage	Pharmaceutical Intermediate; Vonoprazan Fumarate Intermediate / Impurity

Package & Storage:

Package: Fluorinated Bottle, 25kg/Drum, 200kg/Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place. Protect from light and moisture. Store away from strong oxidizing agents.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

Application:

2'-Fluoroacetophenone (CAS: 445-27-2) is a pharmaceutical intermediate, which can be used as a starting material to synthesize Vonoprazan Fumarate (CAS: 1260141-27-2). Vonoprazan Fumarate (Takecab®), discovered and developed by Takeda and Otsuka, was approved by the PMDA of Japan in December 2014, and is indicated for the treatment of gastric ulcer, duodenal ulcer and reflux esophagitis. Vonoprazan Fumarate has a novel mechanism of action called potassium-competitive acid blockers, which competitively inhibit the binding of potassium ions to H+, K+-ATPase (also known as the proton pump) in the final step of gastric acid secretion in gastric parietal cells. Vonoprazan does not inhibit Na+, K+-ATPase activity even at concentrations 500 times higher than that of their IC50 values against gastric H+, K+-ATPase activity. Furthermore, the drug is unaffected by the gastric secretory state, unlike PPIs.